disopyramide – n. 丙吡胺 Norpace – n. 丙吡胺胶囊
procainamide – n. 普鲁卡因胺
quinidine – n. 奎尼丁
lidocaine – n. 利多卡因 Xylocaine – n. 赛露鹰
mexiletine – n. 美西律
flecainide – n. 氟卡尼
propafenone – n. 普罗帕酮 Rythmol – n. 来特莫尔
membrane-stabilizing agent – 膜稳定药
proarrhythmic – a. 致心律失常的
Pronestyl – n. 百浪斯迪
Cardioquin – n. 【奥】卡迪奎宁 注：有“【奥】”标记者为奥医临时用名，只为方便学员复习记忆，不得作为临床诊疗依据！
“RN-ISPN考试复习要点提示”
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————RN/ISPN Review ————
Class I Antiarrhythmics
I类抗心律不齐药
Class I antiarrhythmics are drugs that block the sodium channels in the cell membrane during an action potential. These drugs are further broken down into three subclasses, reflecting the manner in which their blockage of sodium channels affects the action potential. These subclasses include the following:
I类抗心律不齐药为动作电位期间阻断细胞膜钠离子通道的药。这些药物可进一步分为3个次级，以反映这些药物是如何阻断钠离子通道影响动作电位的。这些次级分类药物包括：
l Class Ia antiarrhythmics: Disopyramide (Norpace), procainamide (generic), and quinidine (generic)
类抗心律不齐药：丙吡胺（丙吡胺胶囊）、普鲁卡因胺（通用名）和奎尼丁（通用名）
l Class Ib antiarrhythmics: Lidocaine (Xylocaine) and mexiletine (generic)
类抗心律不齐药：利多卡因（赛露鹰）和美西律（通用名）
l Class Ic antiarrhythmics: Flecainide (generic) and propafenone (Rythmol)
类抗心律不齐药：氟卡尼（通用名）和普罗帕酮（来特莫尔）
The class I antiarrhythmics stabilize the cell membrane by binding to sodium channels, depressing phase 0 of the action potential, and changing the duration of the action potential. Class Ia drugs depress phase 0 of the action potential and prolong the duration of the action potential. Class Ib drugs depress phase 0 somewhat and actually shorten the duration of the action potential. Class Ic drugs markedly depress phase 0, with a resultant extreme slowing of conduction, but have little effect on the duration of the action potential.
These drugs are local anesthetics or membrane-stabilizing agents. They bind more quickly to sodium channels that are open or inactive—ones that have been stimulated and are not yet repolarized. This characteristic makes these drugs preferable in conditions such as tachycardia, in which the sodium gates are open frequently. These drugs are indicated for the treatment of potentially life-threatening ventricular arrhythmias and should not be used to treat other arrhythmias because of the risk of a proarrhythmic effect.
1. Class Ia antiarrhythmic agents have little effect on:
A. AV node
B. SA node
C. Purkinje fibers
D. Bundle of His 2. Which of the following drugs can cause severe hematologic disorders?
A. Digoxin (Lanoxin)
B. Quinidine (Cardioquin)
C. Disopyramide (Norpace)
D. Procainamide (Pronestyl)
奥医教育“在线自测”题库
ISPN/RN复习练习、效果检验一站完成。
答案 Answers 1. B. SA node Rationale: Class Ia antiarrhythmics have little effect on the SA node.
2. D. Procainamide (Pronestyl) Rationale: Pronestyl is known for this serious side effect. Associate Pronestyl with plasma — P and P. This drug is known for its hematologic side effects.
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