angiotensin-converting enzyme -- 血管紧张素转化酶(ACE)
benazepril – n. 贝那普利
Lotensin – n. 洛汀新
captopril – n. 卡托普利
Capoten – n. 开博通
enalapril – n. 依那普利
Vasotec – n. 【奥】维索特克
enalaprilat – n. 依那普利拉
fosinopril – n. 福辛普利
lisinopril – n. 赖诺普利
Prinivil – n. 【奥】普利尼维
Zestril – n. 捷赐瑞
moexipril – n. 莫昔普利
Univasc – n. 【奥】尤尼维斯
perindopril – n. 培哚普利
Aceon – n. 【奥】阿塞昂
quinapril – n. 喹那普利
Accupril – n. 【奥】阿克普利
ramipril – n. 雷米普利
Altace – n. 【奥】阿尔特斯
trandolapril – n. 群多普利
Mavik – n. 【奥】麦维克 注：带“【奥】”标记者为奥医临时用名，只为方便学员复习记忆，不得作为临床诊疗依据！
ACE inhibitors act in the lungs to prevent ACE from converting angiotensin I to angiotensin II, a powerful vasoconstrictor and stimulator of aldosterone release. This action leads to a decrease in BP and in aldosterone secretion, with a resultant slight increase in serum potassium and a loss of serum sodium and fluid.
These drugs are indicated for the treatment of hypertension, alone or in combination with other drugs. They are also used in conjunction with digoxin and diuretics for the treatment of heart failure and left ventricular dysfunction. Their therapeutic effect in these cases is thought to be related to a decrease in cardiac workload associated with the decrease in peripheral resistance and blood volume. They are also approved for the treatment of diabetic nephropathy. It is thought that the decrease in stimulation of the angiotensin receptors in the renal artery will slow the damage to the renal artery that occurs in diabetes.
ACE inhibitors are contraindicated in the presence of allergy to any of the ACE inhibitors to prevent hypersensitivity reactions and with impaired renal function, which could be exacerbated by the effects of this drug in decreasing renal blood flow. Caution should be used in patients with heart failure because the change in hemodynamics could be detrimental in some cases and in those with salt/volume depletion, which could be exacerbated by the drug effects. Women of childbearing age who choose to use one of these drugs should be encouraged to use barrier contraceptives to avoid pregnancy while taking the drug. Use is contraindicated during pregnancy because of the potential for serious adverse effects on the fetus and during lactation because of potential decrease in milk production and effects on the neonate.
1. A 65-year-old male patient is prescribed an ACE inhibitor for the treatment of hypertension. Which medication below is an ACE inhibitor?
A. Metoprolol
B. Benazepril
C. Losartan
D. Amlodipine 2. Which statements below CORRECTLY describe how ACE Inhibitors work? Select all that apply:
A. This group of medications inhibits the renin-angiotensin-aldosterone system (RAAS).
B. ACE Inhibitors prevent the conversion of Angiotensin I to Angiotensin II.
C. ACE Inhibitors prevent Angiotensinogen from converting to Angiotensin I.
D. ACE Inhibitors have a positive chronotropic and negative inotropic effect on the heart.
奥医教育“在线自测”题库
ISPN/RN复习练习、效果检验一站完成。
答案 Answer 1. B. Benazepril Rationale: Benazepril is an ACE Inhibitor. Remember ACE Inhibitors end in PRIL. 2. A and B. Rationale: ACE inhibitors inhibits the renin-angiotensin-aldosterone system (RAAS), which will prevent the conversion of Angiotensin I to Angiotensin II. Options C and D are false statements about these medications.
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