ISPN Review Agents for Herpes Virus and Cytomegalovirus (CMV)
疱疹病毒与巨细胞病毒药
acyclovir (Zovirax) 阿昔洛韦（舒维乐） Dosage/Route
Adult: 5–10 mg/kg q8h IV, IM, or SC, or 200 mg q4h per day for 10 d and then 400 mg PO b.i.d. for 12 mo
Pediatric: 250–500 mg/m2 q8h IV, IM, or SC for 7–10 d, or 20 mg/kg q.i.d. PO for 5 d Indications
Treatment of herpes virus infections
治疗疱疹病毒感染
cidofovir (Vistide) 西多福韦（【奥】维斯泰[西多福韦注射剂]） Dosage/Route
5 mg/kg IV (over 1 h) once weekly for 2 wk, then every other week, with probenecid 2 g PO at 3 h before and 1 g PO at 2 and 8 h after cidofovir infusion
5 mg/kg IV (1小时)，每周一次，共2周。随后隔周一次。西多福韦注射前3h口服丙磺舒2g，西多福韦注射后2h、8h口服丙磺舒1g。 Indications
Treatment of CMV retinitis in AIDS patients
治疗AIDS患者的巨细胞病毒视网膜炎
famciclovir (Famvir) 泛昔洛韦（泛维尔） Dosage/Route
Herpes zoster: 500 mg PO q8h for 7 d
Genital herpes: 125 mg b.i.d. PO for 5 d Indications
Treatment of herpes virus infections such as herpes zoster or shingles and for recurrent episodes of genital herpes
治疗疱疹病毒感染，如带状疱疹，生死器疱疹复发
foscarnet (Foscavir) 膦甲酸（膦甲酸钠） Dosage/Route
Adult: 40–60 mg/kg q8–12h IV given as a 2-h infusion
Pediatric: safety and efficacy not established Indications
Treatment of CMV and acyclovir-resistant mucocutaneous herpes simplex infections in immunocompromised patients
治疗巨细胞病毒及免疫受损患者的阿昔洛韦耐药性皮肤粘膜单纯疱疹感染
ganciclovir (Cytovene) 更昔洛韦（赛美维） Dosage/Route
Adult: 5 m/kg q12h IV given over 1 h for 14–21 d, then over 1 h daily 7 d/wk or 6 mg/kg per day for 5 d/wk for prophylaxis Indications
Long-term treatment and prevention of CMV infection
巨细胞病毒的长期治疗与预防
valacyclovir (Valtrex) 伐昔洛韦（维德思） Dosage/Route
Herpes zoster: 1 g PO t.i.d. for 7 d
Genital herpes: 500 mg b.i.d. PO for 5 d Indications
Treatment of herpes zoster and recurrent genital herpes; cold sores (herpes labialis)
治疗带状疱疹、反复性生死器疱疹；感冒疮（唇疱疹）
valganciclovir (Valcyte) 缬更昔洛韦（万赛维） Dosage/Route
900 mg PO b.i.d. for 21 d, then 900 mg PO once a day for maintenance; reduce dose with renal impairment Indications
Treatment of CMV retinitis in AIDS patients
治疗AIDS患者巨细胞病毒性视网膜炎
Vocabulary for Today
CMV -- Cytomegalovirus 巨细胞病毒
acyclovir – n. 阿昔洛韦
Zovirax – n. 舒维乐
cidofovir – n. 西多福韦
Vistide – n. 维斯泰（西多福韦注射剂）
probenecid – n. 丙磺舒
famciclovir – n. 泛昔洛韦
Famvir – 泛维尔
foscarnet – n. 膦甲酸
Foscavir – n. 膦甲酸钠
ganciclovir – n. 更昔洛韦
Cytovene – n. 赛美维
valacyclovir – n. 伐昔洛韦
Valtrex – n. 维德思
herpes labialis – n. 唇疱疹
valganciclovir – n. 缬更昔洛韦
Valcyte – n. 万赛维
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